To ascertain whether or not the Pro32Pro33 mutation affects the αvβthree receptor–SERT conversation in midbrain synapses, we carried out coimmunoprecipitation experiments.
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Inhibition of focal adhesion kinase (FAK) rescued SERT function in synapses of KI mice, demonstrating that constitutive active FAK signaling downstream in the Pro32Pro33 integrin αvβ3 suppresses SERT activity. Our research recognize a complex regulation of five-HT homeostasis and behaviors by integrin αvβthree, revealing a vital position for integrins in modulating danger for neuropsychiatric Diseases.
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